Rab GTPases as “eat me” signals for selective autophagy

• Published in: The Journal of cell biology Vol. 224; no. 5; p. 1
• Main Author: Zhao, Yan G.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 05.05.2025
• Subjects: Animals; Autophagy; Humans; Mitophagy; rab GTP-Binding Proteins - metabolism; Signal Transduction

Selective autophagy targets specific cellular cargo for degradation. In this issue, Zhao et al. (https://doi.org/10.1083/jcb.202410150) uncovered that Rab GTPases serve as pivotal “autophagy cues” for recruitment of cargo receptors to facilitate mitophagy, lipophagy, and xenophagy, contributing to t...