Rab GTPases as “eat me” signals for selective autophagy

Selective autophagy targets specific cellular cargo for degradation. In this issue, Zhao et al. (https://doi.org/10.1083/jcb.202410150) uncovered that Rab GTPases serve as pivotal “autophagy cues” for recruitment of cargo receptors to facilitate mitophagy, lipophagy, and xenophagy, contributing to t...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 224; no. 5; p. 1
Main Author Zhao, Yan G.
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 05.05.2025
Subjects
Animals
Autophagy
Humans
Mitophagy
rab GTP-Binding Proteins - metabolism
Signal Transduction
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Summary:Selective autophagy targets specific cellular cargo for degradation. In this issue, Zhao et al. (https://doi.org/10.1083/jcb.202410150) uncovered that Rab GTPases serve as pivotal “autophagy cues” for recruitment of cargo receptors to facilitate mitophagy, lipophagy, and xenophagy, contributing to the precise spatiotemporal regulation of selective autophagy.
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ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202502030