Rab GTPases as “eat me” signals for selective autophagy
Selective autophagy targets specific cellular cargo for degradation. In this issue, Zhao et al. (https://doi.org/10.1083/jcb.202410150) uncovered that Rab GTPases serve as pivotal “autophagy cues” for recruitment of cargo receptors to facilitate mitophagy, lipophagy, and xenophagy, contributing to t...
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| Published in | The Journal of cell biology Vol. 224; no. 5; p. 1 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Rockefeller University Press
05.05.2025
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| Abstract | Selective autophagy targets specific cellular cargo for degradation. In this issue, Zhao et al. (https://doi.org/10.1083/jcb.202410150) uncovered that Rab GTPases serve as pivotal “autophagy cues” for recruitment of cargo receptors to facilitate mitophagy, lipophagy, and xenophagy, contributing to the precise spatiotemporal regulation of selective autophagy. |
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| AbstractList | Selective autophagy targets specific cellular cargo for degradation. In this issue, Zhao et al. (https://doi.org/10.1083/jcb.202410150) uncovered that Rab GTPases serve as pivotal "autophagy cues" for recruitment of cargo receptors to facilitate mitophagy, lipophagy, and xenophagy, contributing to the precise spatiotemporal regulation of selective autophagy.Selective autophagy targets specific cellular cargo for degradation. In this issue, Zhao et al. (https://doi.org/10.1083/jcb.202410150) uncovered that Rab GTPases serve as pivotal "autophagy cues" for recruitment of cargo receptors to facilitate mitophagy, lipophagy, and xenophagy, contributing to the precise spatiotemporal regulation of selective autophagy. Selective autophagy targets specific cellular cargo for degradation. In this issue, Zhao et al. (https://doi.org/10.1083/jcb.202410150) uncovered that Rab GTPases serve as pivotal "autophagy cues" for recruitment of cargo receptors to facilitate mitophagy, lipophagy, and xenophagy, contributing to the precise spatiotemporal regulation of selective autophagy. |
| Author | Zhao, Yan G. |
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| Cites_doi | 10.1038/nrm2728 10.15252/embj.201796463 10.1083/jcb.202410150 10.1080/15548627.2015.1110668 10.1038/s41580-021-00392-4 10.1016/j.tcb.2015.08.010 10.1038/s41580-022-00542-2 10.7554/eLife.31326 10.1038/nrm2708 10.1038/s41556-018-0092-5 |
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| Copyright | 2025 Zhao. Copyright Rockefeller University Press 2025 |
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| References | Zhao (2025041010240716900_bib10) 2025 Khaminets (2025041010240716900_bib5) 2016 Yamano (2025041010240716900_bib8) 2018 Mizushima (2025041010240716900_bib2) 2018 Nakatogawa (2025041010240716900_bib1) 2009 Vargas (2025041010240716900_bib4) 2023 Stenmark (2025041010240716900_bib6) 2009 Kern (2025041010240716900_bib7) 2015 Zhao (2025041010240716900_bib3) 2021 Minowa-Nozawa (2025041010240716900_bib9) 2017 |
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| Title | Rab GTPases as “eat me” signals for selective autophagy |
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