Characterization of drug-drug salt forms of metformin and aspirin with improved physicochemical properties

A drug-drug salt was prepared consisting of metformin and aspirin with two crystalline phases characterized. A hydrophilic surface induced recrystallization mechanism was supposed for the transition from anhydrate to hemihydrate. The modulated solubility properties of the dual drug would help to ove...

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Bibliographic Details
Published inCrystEngComm Vol. 21; no. 25; pp. 377 - 3773
Main Authors Zhou, Wen-Xiu, Zhao, Hong-Wei, Chen, Huan-Huan, Zhang, Zai-Yong, Chen, Dong-Ying
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 2019
Subjects
Aspirin
Crystallography
Metformin
Recrystallization
Side effects
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Summary:A drug-drug salt was prepared consisting of metformin and aspirin with two crystalline phases characterized. A hydrophilic surface induced recrystallization mechanism was supposed for the transition from anhydrate to hemihydrate. The modulated solubility properties of the dual drug would help to overcome the associated gastrointestinal side effects to some extent. A salt between two old drugs was synthesized and two phases were discovered with improved physicochemical properties.
Bibliography:For ESI and crystallographic data in CIF or other electronic format see DOI
10.1039/c9ce00377k
Electronic supplementary information (ESI) available: Experimental procedure, characterization data and crystallographic details. CCDC
1860886
and
1860888
ISSN:1466-8033
1466-8033
DOI:10.1039/c9ce00377k