A novel fluorescent probe for hydrazine based on acetyl-deprotection and iminocoumarin formation

• Published in: Journal of photochemistry and photobiology. A, Chemistry. Vol. 390; p. 112262
• Main Authors: Xu, Wenzhi, Li, Xue, Yin, Jiwei, Han, Mengnan, Liu, Weiyan, Yang, Yutao, Li, Wei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2020
• Subjects: Fluorescent probe; Hydrazine; Iminocoumarin; Tandem reaction; Hydrazine; Tandem reaction; Iminocoumarin; Fluorescent probe
• ISSN: 1010-6030; 1873-2666
• DOI: 10.1016/j.jphotochem.2019.112262

[Display omitted] •A new iminocoumarin-based fluorescence enhanced probe was developed for N2H4.•The recognition mechanism was originated from hydrazine triggered tandem reaction.•The LOD of the probe to hydrazine was 0.051 μM (1.62 ppb).•The probe could quantitatively detect hydrazine in tap water.•The probe could sense hydrazine biological cells. Hydrazine has important applications in the field of medicine and chemical industry. However, hydrazine can cause environmental pollution and human injury. Hence, a new iminocoumarin based probe for hydrazine was reported. Hydrazine triggered tandem reaction lead to the formation of iminocoumarin. The inhibition of PET effect and the increase of coplanarity lead to the enhancement of fluorescence. The fluorescence intensity was proportional to the concentration of hydrazine (0.2–50.0 μM). The LOD of the probe for NH2NH2 was 0.051 μM (1.62 ppb). Moreover, the probe could accurately detect hydrazine in tap water. The probe had good cell membrane permeability and could detect hydrazine in biological cells.