Cultured inclusion-body myositis muscle fibers do not accumulate beta-amyloid precursor protein and can be innervated
Cultured muscle fibers from patients with sporadic inclusion-body myositis (s-IBM), similar to normal control muscle fibers, 1) did not have beta-amyloid precursor protein (betaAPP) immunoreactivity; and 2) became normally innervated, as evidenced by the following features: full cross-striation, con...
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Published in | Neurology Vol. 53; no. 9; p. 2184 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
10.12.1999
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Subjects | |
Online Access | Get more information |
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Summary: | Cultured muscle fibers from patients with sporadic inclusion-body myositis (s-IBM), similar to normal control muscle fibers, 1) did not have beta-amyloid precursor protein (betaAPP) immunoreactivity; and 2) became normally innervated, as evidenced by the following features: full cross-striation, continuous contraction, and acetylcholinesterase and acetylcholine receptors accumulated only at neuromuscular junctions. Thus, factors responsible for betaAPP accumulation and denervation-like changes in s-IBM muscle biopsies are not operative in the relatively short-term, non-aged, cultured s-IBM muscle fibers. |
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ISSN: | 0028-3878 |
DOI: | 10.1212/wnl.53.9.2184 |