Enhancement of tumorigenesis by N-nitrosodiethylamine, N-nitrosopyrrolidine and N6(methylnitroso)-adenosine by ethanol

• Published in: Cancer letters Vol. 68; no. 1; pp. 61 - 66
• Main Authors: Anderson, Lucy M., Carter, John P., Driver, Craig L., Logsdon, Daniel L., Kovatch, Robert M., Giner-Sorolla, Alfredo
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 15.01.1993; Elsevier
• Subjects: Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - pharmacology; Chemical agents; Diethylnitrosamine - pharmacology; Drug Interactions; ethanol; Ethanol - toxicity; Female; Lung Neoplasms - chemically induced; lung tumors; Male; Medical sciences; Mice; Mice, Inbred A; N-nitrosodiethylamine; N-nitrosopyrrolidine; N-Nitrosopyrrolidine - pharmacology; N6-(methylnitroso)-adenosine; nitrosamines; Nitrosamines - pharmacology; stomach tumors; thymic lymphomas; Tumors; N 6-(methylnitroso)-adenosine; stomach tumors; nitrosamines; lung tumors; N-nitrosodiethylamine; thymic lymphomas; ethanol; N-nitrosopyrrolidine; Stomach; Poison interaction; Ethanol; Respiratory disease; Toxicity; Nitrosamine; Rodentia; Oral administration; Tumorigenicity; Malignant tumor; Carcinogenesis; Bronchopulmonary; Carcinogen; Vertebrata; Mammalia; Mouse; Animal; Digestive diseases
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/0304-3835(93)90220-4

Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of forestomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5.5-fold increase in lung tumor multiplicity. The inclusion of 15% ethanol with N 6-(methylnitroso)adenosine, given orally to Swiss female mice, led to reduced body weights and shortened survival time related to hemangiosarcoma occurrence or increased incidence of thymic lymphoma, depending on dose of carcinogen. The data provide additional support for the proposal that co-administered ethanol increases the tumorigenicity of nitrosamines by blocking hepatic first-pass clearance.