Relationship between insulin resistance, soluble adhesion molecules, and mononuclear cell binding in healthy volunteers

• Published in: The journal of clinical endocrinology and metabolism Vol. 84; no. 10; pp. 3485 - 3489
• Main Authors: CHEN, N.-G, HOLMES, M, REAVEN, G. M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.10.1999
• Subjects: Aged; Biological and medical sciences; Cardiology. Vascular system; Cell Adhesion Molecules - blood; Coronary heart disease; E-Selectin - blood; Female; Heart; Humans; Insulin Resistance; Intercellular Adhesion Molecule-1 - blood; Male; Medical sciences; Middle Aged; Monocytes - metabolism; Reference Values; Solubility; Vascular Cell Adhesion Molecule-1 - blood; United States; North America; America; Human; Pancreatic hormone; Vascular cell adhesion molecule 1; Intercellular adhesion molecule 1; E Selectin; Cardiovascular disease; Soluble form; Lipoprotein; Coronary heart disease; Insulin; Blood plasma; Target tissue resistance; Binding capacity; Mononuclear cell; Risk factor; Adult; Elderly; Comparative study
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.84.10.3485

The relationship between insulin resistance, soluble adhesion molecules E-selectin (sE-selectin), intracellular adhesion molecule-1 (sICAM-1), and vascular adhesion molecule-1 (sVCAM-1), mononuclear cell binding to cultured endothelium, and lipoprotein concentrations were evaluated in 28 healthy, nondiabetic, and normotensive individuals. The mean (+/-SEM) lipid and lipoprotein concentrations were within the normal rage: cholesterol (199 +/- 18 mg/dL); triglyceride (128 +/- 12 mg/dL); low-density cholesterol (127 +/- 8 mg/dL; and high-density cholesterol (47 +/- 3 mg/dL). The results indicated that degree of insulin resistance was significantly correlated with concentrations of sE-selectin (r = 0.54, P < 0.005), sICAM-1 (r = 0.67, P < 0.001), and sVCAM-1 (r = 0.41, P < 0.05). Furthermore, the relationship between insulin resistance and both sE-selectin and sI-CAM-1 remained statistically significant when adjusted for differences in age, gender, body mass index, and all measures of lipoprotein concentrations. Finally, mononuclear cell binding correlated significantly with concentrations of sE-selectin (r = 0.54, P < 0.005) and sICAM-1 (r = 0.47, P < 0.01). These findings raise the possibility that previously described relationships between soluble adhesion molecules in patients with hypertension, type 2 diabetes, and dyslipidemia may be due to the presence of insulin resistance in these clinical syndromes and suggests that insulin resistance may predispose individuals to coronary heart disease by activation of cellular adhesion molecules.