Non-invasive ventilation for acute exacerbation of COPD with very high PaCO 2 : A randomized controlled trial

Objective: To assess the role of non-invasive positive pressure ventilation (NIPPV) for management of Indian patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Materials and Methods: Forty patients (mean age 57.6 +- 10.8 years; M:F 31:9) with AECOPD with pH <7.35,...

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Published inLung India Vol. 27; no. 3; pp. 125 - 130
Main Authors Khilnani, Gopi, Saikia, Nripen, Banga, Amit, Sharma, Surendra
Format Journal Article
LanguageEnglish
Published Mumbai Medknow Publications and Media Pvt. Ltd 01.07.2010
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
Artificial respiration
Care and treatment
COPD exacerbation
Diagnosis
Drug therapy
Health aspects
Heart rate
Hospitals
Lung diseases, Obstructive
Mortality
non-invasive ventilation
randomized controlled trial
Ventilation
India
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Summary:Objective: To assess the role of non-invasive positive pressure ventilation (NIPPV) for management of Indian patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Materials and Methods: Forty patients (mean age 57.6 +- 10.8 years; M:F 31:9) with AECOPD with pH <7.35, admitted to the intensive care unit were included. Patients were randomized to receive NIPPV (N, n = 20) with conventional therapy or conventional therapy (C, n = 20) alone at admission. NIPPV was given through the nasal mask. Incidence of need of endotracheal intubation (ETI) was the primary efficacy variable. Hospital mortality, duration of hospital stay and change in clinical and blood gas parameters were the secondary outcome variables. Results: Mean pH at baseline for N and C groups were similar (7.23 +- 0.07) whereas PaCO 2 was 85.4 +- 14.8 and 81.1 +- 11.6 mm of Hg, respectively. At one hour, patients in N group had greater improvement in pH (P = 0.017) as well as PaCO 2 (P = 0.04) which corroborated with clinical improvement. Whereas need of ETI was reduced in patients who received NIPPV (3/20 vs 12/20, P = 0.003), in-hospital mortality was similar (3/20 and 2/20, P = NS). The mean duration of hospital stay was significantly shorter in N group (9.4 +- 4.3 days) as compared to C group (17.8 +- 2.6 days); P = 0.001. Conclusions: In patients with AECOPD, NIPPV leads to rapid improvement in blood gas parameters and reduces the need for ETI
ISSN:0970-2113
0974-598X
DOI:10.4103/0970-2113.68308