A CASE OF DIFFUSE-TYPE EARLY GASTRIC CANCER WITH NODULAR GASTRITIS

• Published in: Digestive endoscopy Vol. 18; no. 1; pp. 67 - 70
• Main Authors: Tanabe, Jun, Kawai, Naoki, Abe, Takashi, Ueshima, Nariyuki, Mizutani, Shin, Tsujimoto, Masahiko, Meren, Haruya, Kawano, Sunao, Kamada, Tomoari, Haruma, Ken
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01.01.2006
• Subjects: diffuse-type; gastric cancer; Helicobacter pylori; nodular gastritis; risk factor
• ISSN: 0915-5635; 1443-1661
• DOI: 10.1111/j.1443-1661.2006.00575.x

A 39‐year‐old woman was referred to Osaka Police Hospital and admitted for surgical treatment of gastric cancer. Barium upper gastrointestinal study and endoscopic examination showed a 3.0 × 3.0 cm depressed lesion in the greater curvature of the middle corpus. An unusual miliary pattern resembling ‘goose flesh’ was observed endoscopically in the antrum. Biopsy specimens from the tumor showed poorly differentiated adenocarcinoma, and specimens from the antrum showed many lymphoid follicles with a germinal center. Rapid urease test and histological tests (Giemsa stain) for Helicobacter pylori were both positive. Early gastric cancer with nodular gastritis (NG) was diagnosed and a partial gastrectomy was performed. Histological examination of the resected specimen showed a stage I tumor consisting mainly of signet‐ring cell carcinoma restricted to the mucosa. Postoperatively H. pylori eradication therapy was performed and proved to be successful. One year after eradication therapy, endoscopy with biopsy showed no recurrence of gastric cancer and the remarkable regression of antral NG.