Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction

The ruthenium‐catalyzed azide‐alkyne cycloaddition (RuAAC) gives access to 1,5‐disubstitued triazoles in a single atom‐economical step and offers advantages compared to its copper‐catalyzed counterpart in that both terminal and internal alkynes can be employed. This review summarizes recent findings...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 27; no. 25
Main Authors Ferrara, Flavia, Beke‐Somfai, Tamás, Kann, Nina
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.07.2024
Subjects
alkyne
Alkynes
Chemical synthesis
Cycloaddition
Organic chemistry
Ruthenium
transition-metal catalysis
triazole
Online AccessGet full text

Cover

More Information
Summary:The ruthenium‐catalyzed azide‐alkyne cycloaddition (RuAAC) gives access to 1,5‐disubstitued triazoles in a single atom‐economical step and offers advantages compared to its copper‐catalyzed counterpart in that both terminal and internal alkynes can be employed. This review summarizes recent findings in this field during the last eight years, covering mechanistic investigations, synthetic developments, as well as applications in medicinal chemistry, polymer synthesis and physical organic chemistry. The Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) provides selective access to both 1,5‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles in a single step from alkynes and organic azides. The reaction has quickly made its mark in a wide range of areas, spanning from peptidomimetics and antibacterials, to the preparation of functionalized materials and photoswitches. This review covers progress in RuAAC from 2016 and onwards.
ISSN:1434-193X
1099-0690
1099-0690
DOI:10.1002/ejoc.202400113