Cydophosphamide-Induced Abnormalities in the Incisors of the Rat

A single injection of 75 mg/kg cyclophosphamide caused gross dental abnormalities in rats. Broken, malformed, overgrown, and "extra" incisors developed several weeks after drug treatment. Radioautographic investigations show no unusual features in the morphology or labeling with H3-thymidi...

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Bibliographic Details
Published inJournal of dental research Vol. 56; no. 7; pp. 809 - 816
Main Authors Lee Vahlsing, H., Kim, Sun-Kee, Feringa, Earl R.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.07.1977
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Summary:A single injection of 75 mg/kg cyclophosphamide caused gross dental abnormalities in rats. Broken, malformed, overgrown, and "extra" incisors developed several weeks after drug treatment. Radioautographic investigations show no unusual features in the morphology or labeling with H3-thymidine in the odontogenic cells. The results suggest that the cytotoxic effect of the drug is a temporary one which induces a residual alteration of tooth growth.
ISSN:0022-0345
1544-0591
DOI:10.1177/00220345770560071601