Prolactin stimulation by meals is related to protein content

To study the effect of meals on PRL secretion, serum PRL was measured after the ingestion of mixed meals and specific single macronutrients by normal men and women. In men, only protein feeding significantly stimulated PRL secretion. In women, protein meals as well as a standard mixed meal and a liq...

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Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 57; no. 2; p. 334
Main Authors Carlson, H E, Wasser, H L, Levin, S R, Wilkins, J N
Format Journal Article
LanguageEnglish
Published United States 01.08.1983
Subjects
Adult
Dietary Carbohydrates - pharmacology
Dietary Fats - pharmacology
Dietary Proteins - pharmacology
Female
Food
Glucose - pharmacology
Humans
Kinetics
Male
Middle Aged
Prolactin - secretion
Sex Factors
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Summary:To study the effect of meals on PRL secretion, serum PRL was measured after the ingestion of mixed meals and specific single macronutrients by normal men and women. In men, only protein feeding significantly stimulated PRL secretion. In women, protein meals as well as a standard mixed meal and a liquid mixed meal resulted in PRL release. Fat, glucose, and a nonnutrient meal had no consistent effect on serum PRL. Serum TSH was not altered by any of the meals, and serum GH and cortisol showed few changes. We conclude that PRL stimulation by meals may be of occasional clinical significance, principally in confusing the diagnosis of hyperprolactinemic states, especially in women. Dietary protein is probably the agent responsible for PRL secretion induced by meals.
ISSN:0021-972X
DOI:10.1210/jcem-57-2-334