Intracranial leiomyosarcoma in a patient with AIDS

• Published in: Neuroradiology Vol. 41; no. 1; pp. 35 - 39
• Main Authors: BROWN, H. G, BURGER, P. C, OLIVI, A, SILLS, A. K, BARDITCH-CROVO, P. A, LEE, R. R
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.01.1999
• Subjects: Acquired Immunodeficiency Syndrome - complications; Adult; AIDS/HIV; Biological and medical sciences; Brain - diagnostic imaging; Brain - pathology; Brain Neoplasms - complications; Brain Neoplasms - diagnosis; Brain Neoplasms - pathology; Brain Neoplasms - virology; Epstein-Barr Virus Infections - complications; Female; Herpesvirus 4, Human - isolation & purification; Humans; Leiomyosarcoma - complications; Leiomyosarcoma - diagnosis; Leiomyosarcoma - pathology; Leiomyosarcoma - virology; Magnetic Resonance Imaging; Medical sciences; Neurology; Tomography, X-Ray Computed; Tumors of the nervous system. Phacomatoses; Human; Immunohistochemistry; Immunopathology; Intracranial; Nervous system diseases; Radiodiagnosis; Exploration; Smooth muscle; AIDS; Malignant tumor; Immune deficiency; Nuclear magnetic resonance imaging; Cerebral disorder; Infection; Case study; Pathology; Viral disease; Central nervous system disease; Leiomyosarcoma; Medical imagery; Female; Computerized axial tomography
• ISSN: 0028-3940; 1432-1920
• DOI: 10.1007/s002340050701

We report an intracranial leiomyosarcoma in the pontine cistern of a 34-year-old woman infected with the human immunodeficiency virus (HIV). The clinical, radiological and pathological data are reviewed. The tumor was Epstein-Barr virus (EBV) positive by in situ hybridization. This case emphasizes that smooth muscle neoplasms arising in the setting of immunocompromise can occur intracranially, and corroborates a hypothesis that EBV coinfection may have a role in development of these tumors.