Effect of Cardiopulmonary Bypass on Cancer Prognosis

Adverse effects of cardiopulmonary bypass on cancer prognosis are expected but have not been confirmed. Seventy-four cancer patients who underwent cardiac surgery before cancer therapy were followed up for 42 ± 37 months; 45 had cardiac surgery with cardiopulmonary bypass. There was no significant d...

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Published inAsian cardiovascular & thoracic annals Vol. 18; no. 6; pp. 536 - 540
Main Authors Suzuki, Shuichi, Usui, Akihiko, Yoshida, Katsuhiko, Matsuura, Akio, Ichihara, Toshihiko, Ueda, Yuichi
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.12.2010
Subjects
Aged
Cardiac Surgical Procedures - adverse effects
Cardiac Surgical Procedures - mortality
Cardiopulmonary Bypass - adverse effects
Cardiopulmonary Bypass - mortality
Chi-Square Distribution
Coronary Artery Bypass, Off-Pump
Female
Humans
Japan
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplasms - complications
Neoplasms - mortality
Neoplasms - pathology
Neoplasms - therapy
Retrospective Studies
Risk Assessment
Risk Factors
Survival Rate
Time Factors
Treatment Outcome
Japan
Cardiac Surgical Procedures
Prognosis
Cardiopulmonary Bypass
Neoplasms
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Summary:Adverse effects of cardiopulmonary bypass on cancer prognosis are expected but have not been confirmed. Seventy-four cancer patients who underwent cardiac surgery before cancer therapy were followed up for 42 ± 37 months; 45 had cardiac surgery with cardiopulmonary bypass. There was no significant difference in cancer recurrence (40.0%) and deaths (26.7%) among patients who had cardiopulmonary bypass and those who underwent off-pump cardiac surgery (27.6% and 24.1%). There were no significant differences in freedom from cancer-related death at 2 and 5 years after cardiac surgery (78.4% and 68.5%) in the cardiopulmonary bypass group compared to the 29 off-pump group (81.8% and 58.3%). Despite some limitations, this study detected no significant adverse effects of cardiopulmonary bypass on cancer prognosis. Although these results do not verify the safety of cardiopulmonary bypass from an oncologic aspect, they suggest it can be applied in cancer patients who require cardiac surgery.
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ISSN:0218-4923
1816-5370
DOI:10.1177/0218492310388453