Identification of novel 'expressed sequence tags' within the FHIT gene locus in human chromosome region 3p14.2

• Published in: Human genetics Vol. 100; no. 1; pp. 90 - 95
• Main Authors: LUX, A, BARDENHEUER, W, MICHAEL, D, BRÖCKER, F, JÜLICHER, K, VIETEN, L, MICHAELIS, S, SEEBER, S, OPALKA, B, SCHÜTTE, J
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.07.1997; Berlin; New York, NY
• Subjects: Acid Anhydride Hydrolases; Biological and medical sciences; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 3 - genetics; Classical genetics, quantitative genetics, hybrids; Cloning, Molecular; DNA, Complementary; Fundamental and applied biological sciences. Psychology; Gene Expression; Genes, Tumor Suppressor; Genetics of eukaryotes. Biological and molecular evolution; Human; Humans; Molecular Sequence Data; Neoplasm Proteins - genetics; Polymerase Chain Reaction; Proteins - genetics; Sequence Analysis, DNA; Chromosomal aberration; Genetic mapping; Human; Breakpoint; Genetic marker; Abnormal chromosome; Chromosome A3; Gene expression; Expressed sequence tag; Physical map; Tumor suppressor gene; Chromosome translocation
• ISSN: 0340-6717; 1432-1203
• DOI: 10.1007/s004390050471

Losses of genetic material within human chromosome regions (HCR) 3p12-p14 and 3p21-p22 are observed in various neoplasias, suggesting tumor suppressor gene (TSG) loci within these regions. HCR 3p14 is particularly interesting as it contains the t(3;8) translocation breakpoint of a hereditary renal cell carcinoma, the FRA3B fragile site, and DNA markers deleted in several types of human cancer. We here report on the identification of five novel 'expressed sequence tags' (ESTs) within 3p14.2 which map proximal to exon 9 of the candidate TSG, FHIT. These ESTs may be valuable for elucidation of the supposed TSG content in 3p14.2.