Segregation distortion of X-linked marker genes in interspecific crosses between Mus musculus and M. spretus

An interspecific cross was made between females of the C3H/HeHa.Pgk-1 a inbred laboratory strain of Mus musculus and males of the separate species Mus spretus. The F1 males are sterile but the F1 females are fertile and they were backcrossed to both C3H and spretus males. Evidence is presented from...

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Bibliographic Details
Published inGenome Vol. 29; no. 2; p. 389
Main Author Biddle, F G
Format Journal Article
LanguageEnglish
Published Canada 01.04.1987
Subjects
Animals
Crosses, Genetic
Female
Genes
Genes, Lethal
Genetic Linkage
Infertility, Male
Male
Mice
Mice, Inbred C3H - genetics
Muridae - genetics
Recombination, Genetic
X Chromosome
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Summary:An interspecific cross was made between females of the C3H/HeHa.Pgk-1 a inbred laboratory strain of Mus musculus and males of the separate species Mus spretus. The F1 males are sterile but the F1 females are fertile and they were backcrossed to both C3H and spretus males. Evidence is presented from the segregation of X-linked marker genes that the interspecific F1 female has a genetically deleterious effect on the C3H X chromosome that is expressed as a male-lethal effect with the spretus Y chromosome but not with the musculus Y chromosome of C3H.
ISSN:0831-2796
DOI:10.1139/g87-067