The Role of LncRNA TUG1 in Obesity-Related Diseases

With the continuous improvement of living standards, obesity has become an inevitable hotspot in our daily life. It remains a chronic and recurrent disease with serious adverse consequences. Over the past few years, several articles suggested that long non-coding RNA taurine increased gene 1（lncRNA...

Full description

Saved in:
Bibliographic Details
Published inMini reviews in medicinal chemistry
Main Authors Xue, Mengzhen, Xia, Fangqi, Wang, Yaqi, Zhu, Leiqi, Li, Yuanyang, Jia, Dengke, Gao, Yan, Shi, Ue, Zhang, Changcheng, He, Yumin, Liu, Chaoqi, Yuan, Ding, Yuan, Chengfu
Format Journal Article
LanguageEnglish
Published Netherlands 01.05.2022
Subjects
diseases related to obesity
molecular mechanism
TUG1
exosomes
obesity
Long non-coding RNA
Online AccessGet more information

Cover

More Information
Summary:With the continuous improvement of living standards, obesity has become an inevitable hotspot in our daily life. It remains a chronic and recurrent disease with serious adverse consequences. Over the past few years, several articles suggested that long non-coding RNA taurine increased gene 1（lncRNA TUG1）, a useful RNA, was suggested to show a relationship to obesity-related disease occurrence and development. Exosome is an emerging research field, which contains substances that are actively involved in regulating the molecular mechanisms of disease. This review summarizes the current relevant TUG1 in different molecular pathways of diseases related to obesity, relationship between exosomes and TUG1 or diseases related to obesity. The aim is to explore TUG1 as a novel target for obesity, which can deepen the knowledge regarding epigenetic regulation pathway. Besides, it is likely to be a potential future targeting diseases related to obesity site treatment and diagnosis.
ISSN:1875-5607
DOI:10.2174/1389557522666220117120228