Anticonvulsive drugs and blood levels of lactate, pyruvate, and glucose in children with seizures

Lactate, pyruvate, and glucose were determined in groups of 10 patients, each receiving single drug therapy for their seizure disorder with either phenytoin, valproic acid, carbamazepine, or phenobarbital, and in patients not taking medication. All drug levels were in their therapeutic ranges. The c...

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Bibliographic Details
Published inNeurology Vol. 36; no. 9; p. 1267
Main Authors Carter, A L, Hartlage, P L, Eller, A G, Hommes, F A
Format Journal Article
LanguageEnglish
Published United States 01.09.1986
Subjects
Anticonvulsants - therapeutic use
Blood Glucose - analysis
Humans
Lactates - blood
Pyruvates - blood
Seizures - blood
Seizures - drug therapy
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Summary:Lactate, pyruvate, and glucose were determined in groups of 10 patients, each receiving single drug therapy for their seizure disorder with either phenytoin, valproic acid, carbamazepine, or phenobarbital, and in patients not taking medication. All drug levels were in their therapeutic ranges. The characteristics of the groups were similar, except for the phenytoin group being significantly older. No significant differences were found in glucose or pyruvate concentrations. However, patients on valproic acid had reduced lactate (p less than 0.05) and L/P ratios (p less than 0.05). The reduction in lactate in patients on valproate therapy may mask inborn errors of metabolism that normally result in an increase in blood lactate levels.
ISSN:0028-3878
DOI:10.1212/wnl.36.9.1267