Insulin-like growth factor-1 and myocardial remodeling in female patients with arterial hypertension and metabolic syndrome

• Published in: Rat͡s︡ionalʹnai͡a︡ farmakoterapii͡a︡ v kardiologii Vol. 11; no. 5; pp. 489 - 495
• Main Authors: Zakirova, A. N., Fatkullina, E. R., Zakirova, N. E., Zhamalov, L. M.
• Format: Journal Article
• Language: English
• Published: Столичная издательская компания 01.01.2015
• Subjects: arterial hypertension; insulin-like growth factor-1; myocardial remodeling; obesity
• ISSN: 1819-6446; 2225-3653
• DOI: 10.20996/1819-6446-2015-11-5-489-495

Aim. To establish the role of insulin-like growth factor-1 (IGF-1) in left ventricular remodeling in female patients with arterial hypertension (HT) and metabolic syndrome (MS) with different stages of obesity. Material and methods. The study included 108 women with HT and MS, who were divided into 3 groups according to the stage of obesity, and 28 healthy women. The level of IGF-1, hemodynamic status and types of left ventricular remodeling were assessed. Results. Concentric remodeling and IGF-1 elevation (165.3±12.03 ng/ml) prevailed in patients with HT and first stage of obesity. Concentric hypertrophy of left ventricle and normal level of IGF-1 (118.5±10.05 ng/ml) were established in patients with second stage of obesity. Lack of IGF-1 (96.4±8.11 ng / ml) was determined in women with third stage of obesity and eccentric hypertrophy. Correlation analysis in patients with 2-3 stages of obesity showed significant associations between the level of IGF-1 and hemodynamic parameters. Conclusion. Changes in the level of IGF-1 in patients with AH and MS correlate with types of remodeling and stage of obesity.