Deportation of trophoblastic emboli to maternal lung: A source of cell-free DNA in maternal blood?

During human pregnancy there is a continuous transport of numerous syncytiotrophoblastic cells from the intervillous space of the placenta into the maternal lung. There these cells undergo apoptosis and the fetal nuclear DNA is liberated within the pulmonary capillaries to become cffDNA in the mater...

Full description

Saved in:
Bibliographic Details
Published inChimerism Vol. 1; no. 1; pp. 15 - 18
Main Authors Benirschke, Kurt, Willes, Lawrence
Format Journal Article
LanguageEnglish
Published United States Landes Bioscience 01.07.2010
Subjects
Binding
Biology
Bioscience
Brief Report
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
Online AccessGet full text

Cover

More Information
Summary:During human pregnancy there is a continuous transport of numerous syncytiotrophoblastic cells from the intervillous space of the placenta into the maternal lung. There these cells undergo apoptosis and the fetal nuclear DNA is liberated within the pulmonary capillaries to become cffDNA in the maternal serum. We have examined the sections of lungs of 11 pregnant women (from 8 weeks to term gestation) who had come to the Medical Examiner's Offices after their traumatic demise. We then identified the deported, embolized trophoblastic cells in pulmonary capillaries and showed them to contain hCG immunohistochemically and we also determined their apoptotic profiles.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1938-1956
1938-1964
DOI:10.4161/chim.1.1.12140