A short route to nucleoside diphosphate activated D- and L-hexoses

Leloir transferases utilise nucleoside diphosphate sugars, which are notoriously difficult to synthesise and handle. Starting off from D- or L-configurated glycals, a facile synthesis of nucleotide sugars by epoxidation and direct coupling with uridine diphosphate is described. (C) 2001 Published by...

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Bibliographic Details
Published inTetrahedron letters Vol. 42; no. 16; pp. 2973 - 2975
Main Authors Ernst, C, Klaffke, W
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 16.04.2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
carbohydrates
1,2-anhydride
OLIGOSACCHARIDES
GLYCOSYL DONORS
GLYCALS
SUGARS
nucleoside diphosphate sugars
Leloir-transferase donors
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Summary:Leloir transferases utilise nucleoside diphosphate sugars, which are notoriously difficult to synthesise and handle. Starting off from D- or L-configurated glycals, a facile synthesis of nucleotide sugars by epoxidation and direct coupling with uridine diphosphate is described. (C) 2001 Published by Elsevier Science Ltd.
ISSN:0040-4039
DOI:10.1016/S0040-4039(01)00352-5