Radical-mediated thiol-ene 'click' reactions in deep eutectic solvents for bioconjugation
Herein, we report the first application of deep eutectic solvents (DESs) in radical-mediated hydrothiolation reactions. Under UV and atmospheric-oxygen mediated conditions, the thiol-ene reaction was applied to amino acid and peptide ligation in DESs. The conditions facilitate highly-efficient synth...
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Published in | Green chemistry : an international journal and green chemistry resource : GC Vol. 24; no. 4; pp. 1456 - 1462 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge
Royal Society of Chemistry
21.02.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Herein, we report the first application of deep eutectic solvents (DESs) in radical-mediated hydrothiolation reactions. Under UV and atmospheric-oxygen mediated conditions, the thiol-ene reaction was applied to amino acid and peptide ligation in DESs. The conditions facilitate highly-efficient synthesis of biomolecular targets using a 'green' methodology, with complete recycling of the reaction medium. Fluorescent labelling and glycosylation of a minimal sequence mimetic of angiotensin-converting enzyme 2 capable of binding the SARS-CoV-2 spike protein is demonstrated for applications in the study of inhibition of COVID-19 infectivity.
Herein, we report the first application of deep eutectic solvents (DESs) in radical-mediated hydrothiolation reactions. |
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Bibliography: | 10.1039/d1gc03714e Electronic supplementary information (ESI) available. See DOI |
ISSN: | 1463-9262 1463-9270 |
DOI: | 10.1039/d1gc03714e |