Apolipoprotein A1 and Ceruloplasmin, the key crosstalk players between the liver and adipose tissue during early postpartum of buffaloes: An in-Silico transcriptome based network analysis

• Published in: Computers in biology and medicine Vol. 126; p. 104024
• Main Authors: Sharma, Yuvraj, Verma, Surya Kant, Kumar, Lal Krishan, Surla, Gangu Naidu, Vedamurthy, Gowdar V., Singh, Dheer, Onteru, Suneel Kumar
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.11.2020; Elsevier Limited
• Subjects: Adipose tissue; Animal lactation; Animals; Annotations; Autocrine signalling; Bioinformatics; Bioinformatics analyses; Body fat; Buffalo; Cattle; Ceruloplasmin; Cross-talk; Crosstalk; Datasets; Disaccharides; Endocrine/autocrine molecules; Energy demand; Extracellular matrix; Fatty acids; Galactose; Gene expression; Genes; Genetic crosses; Genomes; Glucose; Glycerol; Lactation; Lactoferrin; Lactose; Ligands; Lipolysis; Liver; Metabolism; Milk; Milk production; Network analysis; Offspring; Ontology; PANTHER; Physiology; Post-partum; Postpartum; Postpartum period; Pregnancy; Proteins; Secretome; Signaling; Software; Post-partum; Adipose tissue; Liver; LT; PPI; ITPR3; Endocrine/autocrine molecules; PANTHER; HDL; DEGs; VLDL; Cross-talk; CC; APOA1; NEB; NEFAs; Bioinformatics analyses; CP; ECM; AT; CPDB; ECR; STRING; NGS; LTF
• ISSN: 0010-4825; 1879-0534
• DOI: 10.1016/j.compbiomed.2020.104024

Physiological transition from pregnancy to lactation during early postpartum creates a high-energy demand in females towards milk production for the survival of new offspring. Ruminant milk contains high amount of lactose, a disaccharide of the glucose and galactose. The milk yield of the animals is also dependent on the lactose amount. In ruminants, glucose is majorly supplied by the liver, which obtains energy from the adipose tissue during energy demands. Therefore, there should be an intricate crosstalk between these two tissues for efficient maintenance of energy for normal physiological needs and milk production. In the present study, we analyzed the transcriptome data previously obtained from the buffalo liver and adipose tissue on the 15th day and 30th day of lactation by using several bioinformatics tools such as PANTHER, Secretome-P, STRING and CPDB. Our analysis identified a total of 24 signaling molecules as interactive players between the liver and adipose tissue during early postpartum of buffaloes. Particularly, the liver appears to interact with the adipose tissue and itself majorly through an endocrine/autocrine molecule, APOA1. Similarly, the adipose tissue appears to interact with the liver and itself majorly through an endocrine/autocrine molecule, CP (ceruloplasmin). The APOA1 and CP may counteract with each other on lipolysis in buffalo adipose tissue because of their common signaling molecules being shared. In addition, the interaction between the adipose derived ceruloplasmin and the liver derived lactoferrin seems to be important during early postpartum of buffaloes. The importance of this interaction needs to be studied in further studies. •The liver and adipose tissue may crosstalk through 24 interactive players in buffalo during early postpartum.•The liver majorly interacts with adipose tissue through an endocrine/autocrine molecule, APOA1, during early postpartum.•The adipose tissue majorly interacts with the liver through an endocrine/autocrine molecule, CP, during early postpartum.•The APOA1 and CP may counteract on lipolysis in adipose tissue because of the common signaling molecules being shared.•The interaction between an adipokine, CP and the LTF from the liver seems to be important during early postpartum..