Canine viruses and multiple sclerosis

Serum and cerebrospinal fluid from multiple sclerosis (MS) patients and control subjects were tested and compared for presence and titer of neutralizing antibody against the most common canine viruses. Canine viruses included canine distemper virus (CDV), canine adenovirus 1 (CAV-1), canine parainfl...

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Bibliographic Details
Published inNeurology Vol. 31; no. 8; p. 944
Main Authors Appel, M J, Glickman, L T, Raine, C S, Tourtellotte, W W
Format Journal Article
LanguageEnglish
Published United States 01.08.1981
Subjects
Adenoviridae - immunology
Adenoviruses, Human - immunology
Adult
Animals
Antibodies, Viral - analysis
Antibodies, Viral - cerebrospinal fluid
Coronaviridae - immunology
Distemper Virus, Canine - immunology
Dogs - microbiology
Female
Herpesviridae - immunology
Humans
Male
Measles virus - immunology
Middle Aged
Multiple Sclerosis - etiology
Multiple Sclerosis - immunology
Multiple Sclerosis - microbiology
Respirovirus - immunology
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Summary:Serum and cerebrospinal fluid from multiple sclerosis (MS) patients and control subjects were tested and compared for presence and titer of neutralizing antibody against the most common canine viruses. Canine viruses included canine distemper virus (CDV), canine adenovirus 1 (CAV-1), canine parainfluenza virus (CPIV), canine herpesvirus (CHV), canine coronavirus (CCV), and canine parvovirus (CPV). Neutralizing titers against measles virus (MV) and human adenovirus 8 (HA8) were also tested. Significantly elevated (p less than 0.05) antibody levels in sera from MS patients were found only against MV and CDV, but this depended upon the study population and the method of evaluation. The CDV-neutralizing component in serum could be absorbed on MV-infected cells. Results of this study failed to establish a link between canine viruses and MS.
ISSN:0028-3878
DOI:10.1212/wnl.31.8.944