Rapidly progressive dementia in a patient with the Lewy body variant of Alzheimer's disease

A 65-year-old woman presented with a mild memory impairment, spatial disorientation, and poor task initiation. Progression was rapid over 3 months. She developed severe apathy, delusions, extrapyramidal features, and psychometrically quantified cognitive deterioration. Her brain showed many neocorti...

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Bibliographic Details
Published inNeurology Vol. 41; no. 8; p. 1178
Main Authors Armstrong, T P, Hansen, L A, Salmon, D P, Masliah, E, Pay, M, Kunin, J M, Katzman, R
Format Journal Article
LanguageEnglish
Published United States 01.08.1991
Subjects
Aged
Alzheimer Disease - pathology
Brain - ultrastructure
Brain Stem - ultrastructure
Cerebral Cortex - ultrastructure
Female
Humans
Immunohistochemistry - methods
Staining and Labeling
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Summary:A 65-year-old woman presented with a mild memory impairment, spatial disorientation, and poor task initiation. Progression was rapid over 3 months. She developed severe apathy, delusions, extrapyramidal features, and psychometrically quantified cognitive deterioration. Her brain showed many neocortical neuritic plaques and neurofibrillary tangles along with neocortical and brainstem Lewy bodies and temporal lobe spongiform vacuolization. This case is the most rapid deterioration documented of a patient with Alzheimer's disease and Lewy bodies.
ISSN:0028-3878
DOI:10.1212/WNL.41.8.1178