Prognostic value of tumor cell proliferation and intratumor microvessel density in advanced gastric cancer treated with curative surgery
To clarify the prognostic value of tumor cell proliferation [proliferating cell nuclear antigen (PCNA)-positive rate assessed by anti-PCNA immunostaining] and intratumor microvessel density (/0.74 mm2, assessed by anti-CD34 immunostaining) in gastric cancer, 192 advanced gastric cancer patients who...
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Published in | International journal of oncology Vol. 13; no. 2; p. 255 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Greece
01.08.1998
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Subjects | |
Online Access | Get more information |
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Summary: | To clarify the prognostic value of tumor cell proliferation [proliferating cell nuclear antigen (PCNA)-positive rate assessed by anti-PCNA immunostaining] and intratumor microvessel density (/0.74 mm2, assessed by anti-CD34 immunostaining) in gastric cancer, 192 advanced gastric cancer patients who underwent curative surgery were investigated. Multivariate analysis showed that the following variables were significantly related to prognosis: age (P=0.029), depth of invasion (P=0.005), lymph node metastasis (P=0.006), lymphatic invasion (P=0.038), venous invasion (P=0.0005), PCNA-positive rate (P=0.049) and intratumor microvessel density (P=0. 011). In conclusion, tumor cell proliferation and intratumor microvessel density were independent prognostic factors in patients with advanced gastric cancer undergoing curative surgery. |
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ISSN: | 1019-6439 |
DOI: | 10.3892/ijo.13.2.255 |