Prognostic value of tumor cell proliferation and intratumor microvessel density in advanced gastric cancer treated with curative surgery

• Published in: International journal of oncology Vol. 13; no. 2; p. 255
• Main Authors: Isozaki, H, Fujii, K, Nomura, E, Mabuchi, H, Hara, H, Sako, S, Nishiguchi, K, Ohtani, M, Tenjo, T, Nohara, T, Tanigawa, N
• Format: Journal Article
• Language: English
• Published: Greece 01.08.1998
• Subjects: Adult; Aged; Cell Division - physiology; Female; Humans; Immunohistochemistry; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local - blood supply; Prognosis; Proliferating Cell Nuclear Antigen - biosynthesis; Retrospective Studies; Stomach Neoplasms - blood supply; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery
• ISSN: 1019-6439
• DOI: 10.3892/ijo.13.2.255

To clarify the prognostic value of tumor cell proliferation [proliferating cell nuclear antigen (PCNA)-positive rate assessed by anti-PCNA immunostaining] and intratumor microvessel density (/0.74 mm2, assessed by anti-CD34 immunostaining) in gastric cancer, 192 advanced gastric cancer patients who underwent curative surgery were investigated. Multivariate analysis showed that the following variables were significantly related to prognosis: age (P=0.029), depth of invasion (P=0.005), lymph node metastasis (P=0.006), lymphatic invasion (P=0.038), venous invasion (P=0.0005), PCNA-positive rate (P=0.049) and intratumor microvessel density (P=0. 011). In conclusion, tumor cell proliferation and intratumor microvessel density were independent prognostic factors in patients with advanced gastric cancer undergoing curative surgery.