P3 recordings in patients with bilateral temporal lobe lesions

We recorded event-related potentials to an acoustic "oddball" paradigm from 19 scalp derivations in five patients (three women and two men; age range, 44 to 56) who had global amnesia following encephalitis. CT and MRI showed severe bilateral lesions of anterior and midtemporal lobes. A P3...

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Bibliographic Details
Published inNeurology Vol. 42; no. 9; p. 1762
Main Authors Onofrj, M, Fulgente, T, Nobilio, D, Malatesta, G, Bazzano, S, Colamartino, P, Gambi, D
Format Journal Article
LanguageEnglish
Published United States 01.09.1992
Subjects
Adult
Amnesia - etiology
Amnesia - pathology
Amnesia - physiopathology
Encephalitis - complications
Evoked Potentials, Auditory - physiology
Female
Humans
Limbic System - pathology
Limbic System - physiopathology
Magnetic Resonance Imaging
Male
Middle Aged
Temporal Lobe - pathology
Temporal Lobe - physiopathology
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Summary:We recorded event-related potentials to an acoustic "oddball" paradigm from 19 scalp derivations in five patients (three women and two men; age range, 44 to 56) who had global amnesia following encephalitis. CT and MRI showed severe bilateral lesions of anterior and midtemporal lobes. A P3 component, with a peak latency within the normal limits for age-matched controls, was recorded to "target" stimuli in four patients from all leads except Fp1, Fp2, F7, F8, T3, and T4. In the fifth patient, the P3 peak was delayed.
ISSN:0028-3878
DOI:10.1212/WNL.42.9.1762