The first-row transition metal-catalysed enantioconvergent radical Suzuki-Miyaura C(sp)-C coupling of racemic alkyl halides
The enantioconvergent radical Suzuki-Miyaura cross-coupling of racemic alkyl halides represents a powerful approach for the construction of valuable C(sp 3 )-C bonds. In this regard, the earth-abundant first-row transition metal (Ni, Fe, Co, and Cu) catalyst possesses a good single-electron transfer...
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| Published in | Green chemistry : an international journal and green chemistry resource : GC Vol. 26; no. 5; pp. 2525 - 2533 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge
Royal Society of Chemistry
04.03.2024
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The enantioconvergent radical Suzuki-Miyaura cross-coupling of racemic alkyl halides represents a powerful approach for the construction of valuable C(sp
3
)-C bonds. In this regard, the earth-abundant first-row transition metal (Ni, Fe, Co, and Cu) catalyst possesses a good single-electron transfer ability and can easily convert racemic alkyl halides to the prochiral alkyl radicals, providing an ideal solution for enantioconvergence. The utilization of chiral ligands would further facilitate the realization of enantioselective control over the prochiral alkyl radicals. This Perspective will discuss the advances and anticipate further development in this burgeoning field.
This perspective highlights recent advances and provides an outlook on future developments in the first-row transition metal catalysed enantioconvergent radical Suzuki-Miyaura C(sp
3
)−C coupling of racemic alkyl halides. |
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| Bibliography: | Zhong-Liang Li obtained his B.Sc. degree from University of Science and Technology of China in 2009 and Ph.D. degree from The University of Hong Kong in 2014 under the supervision of Professor Dan Yang. In 2015, he did his postdoctoral research with Professor Xin-Yuan Liu and then a research associate professor at Southern University of Science and Technology. He now focuses on asymmetric radical reactions. Qiang-Shuai Gu completed his B.Sc. studies in 2008 from University of Science and Technology of China (USTC) and received his Ph.D. degree in 2013 from The University of Hong Kong (HKU) under the guidance of Professor Dan Yang. He continued his research career first in Professor Yang's group at HKU and later in Professor Xin-Yuan Liu's group at Southern University of Science and Technology (SUSTech). Now, he is a research associate professor in Academy for Advanced Interdisciplinary Studies at SUSTech. His research interests include asymmetric catalysis and asymmetric synthesis of bioactive small molecules. Lin Liu obtained his B.Sc. degree and Ph.D. degree from Lanzhou University in 2013 and 2018 under the supervision of Professor Yong-Qiang Tu, respectively. In 2019, he continued postdoctoral research with Professor Xin-Yuan Liu and later worked as a senior research fellow at Southern University of Science and Technology. Since 2022, he began his academic career as an assistant professor at Great Bay University. His current research interest involves transition metal-catalyzed radical transformations and asymmetric synthesis. Xin-Yuan Liu obtained the B.Sc. degree from Anhui Normal University (AHNU) and Master degree from Shanghai Institute of Organic Chemistry, CAS and AHNU under the jointly supervision of Professor Shizheng Zhu and Professor Shaowu Wang. He earned his Ph.D. degree from The University of Hong Kong under supervision of Professor Chi-Ming Che in 2010. He continued postdoctoral study in the University of Hong Kong and The Scripps Research Institute. In 2012, he began his academic career at Southern University of Science and Technology and was promoted to Chair Professor in 2022. His research interest is radical asymmetric chemistry. Chang-Jiang Yang obtained his B.Sc. degree from Hunan Normal University in 2011 and Ph.D. degree from Nankai University in 2017 under the supervision of Professor Zhengjie He. In 2018, he did his postdoctoral research with Professor Xin-Yuan Liu and then a senior research fellow in Southern University of Science and Technology until 2022. Now he is an assistant professor at Great Bay University. His research interest is the construction of carbon-based quaternary stereocenters and heteroatom stereocenters the catalytic asymmetric approach. via ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| ISSN: | 1463-9262 1463-9270 |
| DOI: | 10.1039/d3gc02793g |