Synthesis of 2-substituted indoles by iridium (III)-catalyzed C-H functionalization of N-phenylpyridin-2-amines

A highly regioselective synthesis of 2-substituted indoles was realized through Ir(III)-catalyzed C-H functionalization of N-phenylpyridin-2-amines followed by the reaction with sulfoxonium ylides and intramolecular cyclization under mild conditions. The reaction completed with broad range of substr...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 60; no. 15; pp. 1053 - 1056
Main Authors Zhang, Lei, Chen, Junyu, Chen, Jinkang, Jin, Licheng, Zheng, Xiangyun, Jiang, Xinpeng, Yu, Chuanming
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 11.04.2019
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ACYLMETHYLATION
ACTIVATION
ANNULATION
Indole
ALLYLATION
ARYLATION
AMIDATION
C-H functionalization
Sulfoxonium ylides
AMINATION
ANILINES
Iridium
CYCLIZATION
Online AccessGet full text

Cover

More Information
Summary:A highly regioselective synthesis of 2-substituted indoles was realized through Ir(III)-catalyzed C-H functionalization of N-phenylpyridin-2-amines followed by the reaction with sulfoxonium ylides and intramolecular cyclization under mild conditions. The reaction completed with broad range of substrate scopes and gave various 2-substituted indoles in up to 98% yields. (C) 2019 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2019.03.027