Magnetic resonance imaging of the brain in patients with anosmia and hypothalamic hypogonadism (Kallmann's syndrome)

Kallmann's syndrome is characterized by hypogonadotropic hypogonadism and anosmia. Postmortem studies have revealed either hypoplasia or aplasia of the rhinencephalon, respectively, in patients with hyposmia and anosmia. This anatomical defect has now been demonstrated in vivo in four patients...

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Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 65; no. 3; p. 581
Main Authors Klingmüller, D, Dewes, W, Krahe, T, Brecht, G, Schweikert, H U
Format Journal Article
LanguageEnglish
Published United States 01.09.1987
Subjects
Adult
Brain - pathology
Follicle Stimulating Hormone - blood
Humans
Hypogonadism - diagnosis
Hypothalamic Diseases - diagnosis
Luteinizing Hormone - blood
Magnetic Resonance Spectroscopy
Male
Olfaction Disorders - diagnosis
Testosterone - blood
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Summary:Kallmann's syndrome is characterized by hypogonadotropic hypogonadism and anosmia. Postmortem studies have revealed either hypoplasia or aplasia of the rhinencephalon, respectively, in patients with hyposmia and anosmia. This anatomical defect has now been demonstrated in vivo in four patients with Kallmann's syndrome by magnetic resonance imaging.
ISSN:0021-972X
DOI:10.1210/jcem-65-3-581