Rhabdomyolysis and myoglobinemia in neonates

Serial myoglobin determinations were made in 20 neonates during the first week of life to determine whether birth asphyxia results in ischemic damage to muscle with the subsequent pathologic release of myoglobin. Serum myoglobin values were significantly elevated in asphyxiated infants compared with...

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Bibliographic Details
Published inPediatrics (Evanston) Vol. 76; no. 2; p. 255
Main Authors Kasik, J W, Leuschen, M P, Bolam, D L, Nelson, R M
Format Journal Article
LanguageEnglish
Published United States 01.08.1985
Subjects
Asphyxia Neonatorum - enzymology
Creatine Kinase - blood
Fetal Blood
Humans
Infant, Newborn
Kidney Function Tests
Myoglobin - blood
Oliguria - enzymology
Rhabdomyolysis - enzymology
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Summary:Serial myoglobin determinations were made in 20 neonates during the first week of life to determine whether birth asphyxia results in ischemic damage to muscle with the subsequent pathologic release of myoglobin. Serum myoglobin values were significantly elevated in asphyxiated infants compared with control infants. High myoglobin values correlated with a longer duration of oliguria in the neonatal intensive care unit population. The value of urine dipstick testing for myoglobinuria screening was also evaluated. Infants with elevated myoglobin values were more likely to have a strongly positive urine dipstick for occult blood in the first 48 hours of life. These data suggest that ischemic damage to muscle with pathologic release of myoglobin occurs in the neonatal period and that urine dipstick testing provides a reasonable screening examination for myoglobinuria.
ISSN:0031-4005
DOI:10.1542/peds.76.2.255