TiCl4-Mediated Baylis-Hillman and aldol reactions without the direct use of a Lewis base
TiCl4-Mediated Baylis-Hillman and aldol reactions were developed without the direct use of a Lewis base. These processes involve the conjugate addition of TiCl4 to alpha,beta-unsaturated substrates followed by carbonyl coupling. Baylis-Hillman olefins were obtained when alpha,beta-unsaturated ketone...
Saved in:
Published in | Tetrahedron letters Vol. 41; no. 1; pp. 1 - 5 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
01.01.2000
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | TiCl4-Mediated Baylis-Hillman and aldol reactions were developed without the direct use of a Lewis base. These processes involve the conjugate addition of TiCl4 to alpha,beta-unsaturated substrates followed by carbonyl coupling. Baylis-Hillman olefins were obtained when alpha,beta-unsaturated ketones were employed as the substrates, whereas beta-halogenated aldol products were generated with an alpha,beta-unsaturated N-acyl benzoxalinone as the Michael-type acceptor. (C) 1999 Elsevier Science Ltd. All rights reserved. |
---|---|
ISSN: | 0040-4039 |
DOI: | 10.1016/S0040-4039(99)01992-9 |