Circulating Polymorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSCs) Have a Biological Role in Patients with Primary Myelofibrosis

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by a chronic inflammatory state that plays a relevant role in the disease pathogenesis (as proven by high levels of inflammatory cytokines with prognostic significance and by a persistent oxidative stress) and by extensive ne...

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Published inCancers Vol. 16; no. 14; p. 2556
Main Authors Campanelli, Rita, Carolei, Adriana, Catarsi, Paolo, Abbà, Carlotta, Boveri, Emanuela, Paulli, Marco, Gentile, Raffaele, Morosini, Monica, Albertini, Riccardo, Mantovani, Stefania, Massa, Margherita, Barosi, Giovanni, Rosti, Vittorio
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.07.2024
Subjects
Bone marrow
Cancer therapies
Chemokines
CXCR4 protein
Cytokines
Development and progression
Genetic diversity
Granulocytes
Immune response
Immunosurveillance
Inflammation
Mutation
Myelofibrosis
Neoplasia
Oxidative stress
Pathogenesis
Patients
Phenotypic variations
Plasma
Sepsis
Spleen
Suppressor cells
Tumors
Variables
United States > US
primary myelofibrosis
inflammation
myeloid-derived suppressor cells
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Summary:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by a chronic inflammatory state that plays a relevant role in the disease pathogenesis (as proven by high levels of inflammatory cytokines with prognostic significance and by a persistent oxidative stress) and by extensive neoangiogenesis in bone marrow (BM) and spleen. Myeloid-derived suppressor cells (MDSCs) are immature cells that expand in patients with cancer, sepsis or chronic inflammation, favoring tumor onset and progression mainly through the decrease in immune surveillance and the promotion of neoangiogenesis. In this paper, we evaluated the presence of circulating MDSCs in PMF patients, the plasmatic factors involved in their mobilization/expansion and the correlations with laboratory, genetic and clinical parameters. The data indicated that MDSCs could have a relevant role in PMF as a new pathogenic mechanism contributing to explaining the phenotypic diversity observed during the clinical course of the disease, or a potential new target for personalized treatment.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16142556