Neuronal apoptosis in neurodegeneration
Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegen...
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| Published in | Antioxidants & redox signaling Vol. 9; no. 8; p. 1059 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.08.2007
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegeneration, a multifaceted process that leads to various chronic disease states, such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) diseases, amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and diabetic encephalopathy. The current review focuses on two major areas (a) the fundamentals of apoptosis, which includes elements of the apoptotic machinery, apoptosis inducers, and emerging concepts in apoptosis research, and (b) apoptotic involvement in neurodegenerative disorders, neuroprotective treatment strategies/modalities, and the mechanisms of, and signaling in, neuronal apoptosis. Current and new experimental models for apoptosis research in neurodegenerative diseases are also discussed. |
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| AbstractList | Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegeneration, a multifaceted process that leads to various chronic disease states, such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) diseases, amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and diabetic encephalopathy. The current review focuses on two major areas (a) the fundamentals of apoptosis, which includes elements of the apoptotic machinery, apoptosis inducers, and emerging concepts in apoptosis research, and (b) apoptotic involvement in neurodegenerative disorders, neuroprotective treatment strategies/modalities, and the mechanisms of, and signaling in, neuronal apoptosis. Current and new experimental models for apoptosis research in neurodegenerative diseases are also discussed. |
| Author | Maracine, Magdalena Ekshyyan, Oleksandr Okouchi, Masahiro Aw, Tak Yee |
| Author_xml | – sequence: 1 givenname: Masahiro surname: Okouchi fullname: Okouchi, Masahiro organization: Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan – sequence: 2 givenname: Oleksandr surname: Ekshyyan fullname: Ekshyyan, Oleksandr – sequence: 3 givenname: Magdalena surname: Maracine fullname: Maracine, Magdalena – sequence: 4 givenname: Tak Yee surname: Aw fullname: Aw, Tak Yee |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17571960$$D View this record in MEDLINE/PubMed |
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| Title | Neuronal apoptosis in neurodegeneration |
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