Conducting multiple-site clinical trials in medical rehabilitation research
This article examines the distinctive opportunities and challenges of multiple-site clinical trials, as distinguished from trials conducted by a single program. Among the topics discussed are: the role of clinical trials generally in medical rehabilitation research; definitions of "clinical tri...
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Published in | American journal of physical medicine & rehabilitation Vol. 84; no. 11; p. 823 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
01.11.2005
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Subjects | |
Online Access | Get more information |
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Summary: | This article examines the distinctive opportunities and challenges of multiple-site clinical trials, as distinguished from trials conducted by a single program. Among the topics discussed are: the role of clinical trials generally in medical rehabilitation research; definitions of "clinical trials" and "multiple site"; the distinction between exploratory and capstone trials; the potential advantages and disadvantages of multiple-site trials; planning issues in terms of sampling designs, the choice of outcome measures, approaches to dealing with intervention fidelity, organizational structures, authorship, and the conduct of collateral studies; and implementation issues in terms of pilot-testing procedures, handling emerging issues, and optimizing communication. |
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ISSN: | 0894-9115 |
DOI: | 10.1097/01.phm.0000184103.57599.01 |