Altohyrtin A, a potent anti-tumor macrolide from the Okinawan marine sponge Hyrtios altum

Altohyrtin A ( 1) has been isolated from the Okinawan marine sponge Hyrtios altum and the plane structure and parts of its relative configurations elucidated. Altohyrtin A ( 1) exhibited extremely potent cytotoxicity against KB cells at IC 50 0.01 ng/ml. The plane structure and parts of the relative...

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Published inTetrahedron letters Vol. 34; no. 17; pp. 2795 - 2798
Main Authors Kobayashi, Motomasa, Aoki, Shunji, Sakai, Haruhiko, Kawazoe, Kazuyoshi, Kihara, Noriaki, Sasaki, Takuma, Kitagawa, Isao
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.04.1993
Elsevier
Subjects
Analytical, structural and metabolic biochemistry
Aromatic and heterocyclic compounds
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Heterocyclic compounds, pigments
Other biological molecules
Antineoplastic agent
Acetal
Molecular structure
Porifera
Isolation
Invertebrata
Oxygen heterocycle
NMR spectrum
Macrolide
Spiran
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Summary:Altohyrtin A ( 1) has been isolated from the Okinawan marine sponge Hyrtios altum and the plane structure and parts of its relative configurations elucidated. Altohyrtin A ( 1) exhibited extremely potent cytotoxicity against KB cells at IC 50 0.01 ng/ml. The plane structure and parts of the relative configurations of Altohyrtin A have been elucidated. Altohyrtin A exhibited extremely potent cytotoxicity against KB cells at IC 50 0.01 ng/ml.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)73564-7