Cutaneous Squamous Cell Carcinoma: An Updated Review

• Published in: Cancers Vol. 16; no. 10; p. 1800
• Main Authors: Jiang, Rina, Fritz, Mike, Que, Syril Keena T
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.05.2024
• Subjects: Antimitotic agents; Antineoplastic agents; Arsenic; B cells; Cancer therapies; Care and treatment; Development and progression; Environmental factors; Epidemiology; Genotype & phenotype; Health aspects; HIV; Human immunodeficiency virus; Human papillomavirus; Hydrochlorothiazide; Immunocompetence; Kinases; Medical prognosis; Melanoma; Metastases; Metastasis; Mortality; Mutation; Pathogenesis; Proteins; Radiation; Risk factors; Risk groups; Skin; Skin cancer; Squamous cell carcinoma; Systematic review; Transplants & implants; Tumorigenesis; United States > US; cutaneous squamous cell carcinoma; American Joint Commission on Cancer; Brigham and Women’s Hospital staging system; chemoprophylaxis; immunotherapy; radiation therapy
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers16101800

Representing the second most common skin cancer, the incidence and disease burden of cutaneous squamous cell carcinoma (cSCC) continues to increase. Surgical excision of the primary site effectively cures the majority of cSCC cases. However, an aggressive subset of cSCC persists with clinicopathological features that are indicative of higher recurrence, metastasis, and mortality risks. Acceleration of these features is driven by a combination of genetic and environmental factors. The past several years have seen remarkable progress in shaping the treatment landscape for advanced cSCC. Risk stratification and clinical management is a top priority. This review provides an overview of the current perspectives on cSCC with a focus on staging, treatment, and maintenance strategies, along with future research directions.