Absence of mutations in the coding region of the alpha-synuclein gene in pathologically proven Parkinson's disease

A missense mutation of the alpha-synuclein gene has been associated with parkinsonism in a large Italian kindred. Recently, alpha-synuclein was also identified in Lewy bodies. Using reverse transcribed-polymerase chain reaction (RT-PCR) technique, we sequenced the entire coding region of the alpha-s...

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Bibliographic Details
Published inNeurology Vol. 50; no. 4; p. 1136
Main Authors Chan, P, Jiang, X, Forno, L S, Di Monte, D A, Tanner, C M, Langston, J W
Format Journal Article
LanguageEnglish
Published United States 01.04.1998
Subjects
Adult
Aged
alpha-Synuclein
DNA Mutational Analysis
DNA, Complementary
Female
Humans
Male
Nerve Tissue Proteins - genetics
Parkinson Disease - genetics
Point Mutation
Polymerase Chain Reaction
Synucleins
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Summary:A missense mutation of the alpha-synuclein gene has been associated with parkinsonism in a large Italian kindred. Recently, alpha-synuclein was also identified in Lewy bodies. Using reverse transcribed-polymerase chain reaction (RT-PCR) technique, we sequenced the entire coding region of the alpha-synuclein gene using brain tissue from 24 pathologically proven Parkinson's disease cases. No mutations were found in any of the patients, suggesting that a mutation at the coding region of the alpha-synuclein gene is unlikely to be responsible for nigrostriatal degeneration in typical sporadic Parkinson's disease.
ISSN:0028-3878
DOI:10.1212/WNL.50.4.1136