Recent progress in the total synthesis of pyrrole-containing natural products (2011–2020)

Natural products have long served as a rich resource for drug discovery in the treatment of illnesses and chronic diseases. Among many families exhibiting fascinating structural complexity and impressive bioactivity, pyrrole-containing natural products frequently present a significant challenge to p...

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Bibliographic Details
Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 8; no. 19; pp. 5550 - 5573
Main Authors Singh, Nidhi, Singh, Snigdha, Kohli, Sahil, Singh, Aarushi, Asiki, Hannah, Rathee, Garima, Chandra, Ramesh, Anderson, Edward A
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 07.10.2021
Subjects
Biological activity
Chemists
Chronic illnesses
Complexity
Natural products
Organic chemistry
Pyrroles
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Summary:Natural products have long served as a rich resource for drug discovery in the treatment of illnesses and chronic diseases. Among many families exhibiting fascinating structural complexity and impressive bioactivity, pyrrole-containing natural products frequently present a significant challenge to practitioners of organic synthesis. As a result, synthetic chemists have paid intense attention to the construction of such frameworks, not least as the amounts of natural product isolated from their natural source is often far less than that needed for biological testing. This review discusses total syntheses of pyrrole-containing natural products over the last ten years, highlighting recent advances in the chemistry of pyrroles both in the context of their innate reactivity, and their preparation in complex settings.
ISSN:2052-4110
2052-4110
DOI:10.1039/d0qo01574a