Non-AIDS-related lymphomatous meningitis: combined modality therapy

Twenty-two patients (age range, 38 to 69 years; median, 60 years) with lymphomatous meningitis due to metastatic non-AIDS-related non-Hodgkin's lymphoma were treated. Cytologic responses were seen in 16 patients (73%) to first-line chemotherapy, 7 patients (58%) to second-line chemotherapy, and...

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Bibliographic Details
Published inNeurology Vol. 49; no. 6; p. 1728
Main Authors Chamberlain, M C, Kormanik, P A
Format Journal Article
LanguageEnglish
Published United States 01.12.1997
Subjects
Adult
Aged
Antimetabolites, Antineoplastic - administration & dosage
Antineoplastic Agents, Alkylating - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cytarabine - administration & dosage
Humans
Lymphoma, Non-Hodgkin - complications
Lymphoma, Non-Hodgkin - drug therapy
Meningitis - etiology
Methotrexate - administration & dosage
Middle Aged
Neoplasm Metastasis
Prospective Studies
Survival Analysis
Thiotepa - administration & dosage
Treatment Outcome
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Summary:Twenty-two patients (age range, 38 to 69 years; median, 60 years) with lymphomatous meningitis due to metastatic non-AIDS-related non-Hodgkin's lymphoma were treated. Cytologic responses were seen in 16 patients (73%) to first-line chemotherapy, 7 patients (58%) to second-line chemotherapy, and 2 patients (40%) to third-line chemotherapy. Median survival was 10 months (range, 3 to 24 months).
ISSN:0028-3878
DOI:10.1212/WNL.49.6.1728