pH sensitive water-in-water emulsions based on the pullulan and poly(,-dimethylacrylamide) aqueous two-phase system

Aqueous-two phase systems (ATPS) and water-in-water (w/w) emulsions are a major topic in chemistry and biology, mainly due to their biocompatibility and various applications. In here, the ATPS formed from poly( N , N -dimethylacrylamide) (PDMA) with three different molar masses (24k - 10 6 g mol −1...

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Published inPolymer chemistry Vol. 13; no. 28; pp. 417 - 4177
Main Authors Plucinski, Alexander, Schmidt, Bernhard V. K. J
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 19.07.2022
Subjects
Binary systems
Biocompatibility
Biomolecules
Block copolymers
Emulsions
Polymer chemistry
Pullulan
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Summary:Aqueous-two phase systems (ATPS) and water-in-water (w/w) emulsions are a major topic in chemistry and biology, mainly due to their biocompatibility and various applications. In here, the ATPS formed from poly( N , N -dimethylacrylamide) (PDMA) with three different molar masses (24k - 10 6 g mol −1 ) and commercial pullulan is investigated. Additionally, the ATPS with ultra-high molecular weight PDMA was transformed into a w/w emulsion using a pH-responsive block copolymer as stabiliser. The w/w emulsion could be destabilised or stabilised, depending on the current pH. The novel pH sensitive w/w emulsion will open up new pathways for example for the encapsulation of biomolecules. A novel aqueous two-phase system based on pullulan and poly( N,N -dimethylacrylamide) is presented. Furthermore, it is used for the formation of pH sensitive water-in-water emulsions.
Bibliography:https://doi.org/10.1039/d2py00469k
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1759-9954
1759-9962
DOI:10.1039/d2py00469k