Isolation and characterization of compounds with anti-prostate cancer activity from Arctium lappa L. using bioactivity-guided fractionation

The methanolic extract of the seeds of Arctium lappa was found to show inhibitory activity against prostate cancer cell lines. Bioactivity-guided fractionation of a 95% ethanol extract from the seeds of A. lappa led to the isolation of seven compounds: -sitosterol (1), daucosterol (2), lappaol C (3)...

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Published inPharmaceutical biology Vol. 42; no. 1; pp. 44 - 48
Main Authors Ming, D.S, Guns, E.S, Eberding, A, Towers, G.H.N
Format Journal Article
LanguageEnglish
Published Lisse Informa UK Ltd 01.01.2004
Taylor & Francis
Swets & Zeitlinger
Subjects
and arctignan E. Lappaol F
and arctiin
anti-prostate cancer cell line
Arctium lappa
Biological and medical sciences
daucosterol
General pharmacology
lappaol A
lappaol C
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
β-sitosterol
Fractionation
Pharmacognosy
Isolation
Malignant tumor
Urogenital system
Prostate
Medicinal plant
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Summary:The methanolic extract of the seeds of Arctium lappa was found to show inhibitory activity against prostate cancer cell lines. Bioactivity-guided fractionation of a 95% ethanol extract from the seeds of A. lappa led to the isolation of seven compounds: -sitosterol (1), daucosterol (2), lappaol C (3), lappaol A (4), and arctignan E (5), lappaol F (6), and arctiin (7). Their structures were elucidated by UV, IR, MS, and NMR data, as well as by comparison with those of the literature. Compounds 3-7 were studied for their cytotoxicity using a prostate cancer cell line. Compounds 3, 4, and 6 showed activity against the LNCaP prostate cancer cell line with IC50 values of 8, 16, and 40 µg/mL, respectively.
ISSN:1388-0209
1744-5116
DOI:10.1080/13880200490505474