LL-Z1271α: An Interleukin-1β Production Inhibitor

LL-Z1271α, a fungal metabolite, dose-dependently inhibited interleukin-1β (IL-1β) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271α to LPS-challenged mice caused significant lowering in the IL-1β levels in peritoneal cavity. Data presented suggest...

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Published inBiochemical and biophysical research communications Vol. 286; no. 4; pp. 697 - 700
Main Authors Ichikawa, Katsuomi, Inagaki, Taisuke, Kachi-Tonai, Hiroko, Kojima, Yasuhiro, Nakamura, Taka-aki, Nishida, Hiroyuki, Ueno, Yoshinobu, Binding, Peter, Gabel, Christopher A., Lucas, Val, McNiff, Patricia A., Kojima, Nakao
Format Journal Article
LanguageEnglish
Published Elsevier Inc 31.08.2001
Subjects
ATP
interleukin 1^b inhibitors
lipopolysaccharides
LL-Z1271^a
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Summary:LL-Z1271α, a fungal metabolite, dose-dependently inhibited interleukin-1β (IL-1β) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271α to LPS-challenged mice caused significant lowering in the IL-1β levels in peritoneal cavity. Data presented suggest that LL-Z1271α inhibits IL-1β production by a novel mechanism as the inhibitory activity was not due to effects on caspase-1 (IL-1β converting enzyme), the ATP-induced release mechanism or a lysosomotrophic effect.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.2001.5458