3D bioengineered tissues: From advancements in in vitro safety to new horizons in disease modeling

Research aimed at more fully emulating human biology in vitro has rapidly progressed in recent years with advancements in 3D tissue engineering and microphysiological systems. The initial target of such systems has been directed towards drug and chemical safety assessment, with the goal of improving...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 101; no. 4; p. 453
Main Authors Hardwick, R N, Viergever, C, Chen, A E, Nguyen, D G
Format Journal Article
LanguageEnglish
Published United States 01.04.2017
Subjects
Animals
Disease Models, Animal
Humans
Imaging, Three-Dimensional
Physiological Phenomena
Tissue Engineering - trends
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Summary:Research aimed at more fully emulating human biology in vitro has rapidly progressed in recent years with advancements in 3D tissue engineering and microphysiological systems. The initial target of such systems has been directed towards drug and chemical safety assessment, with the goal of improving sensitivity and predictive capabilities. Here we discuss recent developments of in vitro organ culture systems, and their future applications in modeling human disease.
ISSN:1532-6535
DOI:10.1002/cpt.569