Catalytic Asymmetric Conjugate Addition of Tritylthiol to Azadienes with a Bifunctional Organocatalyst
A highly enantioselective sulfa-Michael addition of tritylthiol to azadienes catalyzed by a bifunctional squaramide organocatalyst is described, giving the chiral aminothioethers bearing benzofuran motif with high yields and up to 94% of enantioselectivity. Notably, the aromatization to form the ben...
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Published in | Asian journal of organic chemistry Vol. 7; no. 8; pp. 1561 - 1564 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
01.08.2018
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Subjects | |
Online Access | Get more information |
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Summary: | A highly enantioselective sulfa-Michael addition of tritylthiol to azadienes catalyzed by a bifunctional squaramide organocatalyst is described, giving the chiral aminothioethers bearing benzofuran motif with high yields and up to 94% of enantioselectivity. Notably, the aromatization to form the benzofuran is the driving force. |
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ISSN: | 2193-5807 2193-5815 |
DOI: | 10.1002/ajoc.201800299 |