Copper‐Catalyzed Four‐Component Cascade Reaction for the Construction of Triazoles Bearing β‐Hydroxy Chalcogenides

A copper‐catalyzed four‐component cascade reaction for the preparation of triazoles bearing β‐hydroxy chalcogenides from terminal alkynes, azides, epoxides, and Se/K2S is reported. The present reaction proceeds under mild conditions, and exhibits a good functional group compatibility. A possible mec...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 364; no. 1; pp. 165 - 171
Main Authors Wang, Xiang‐Xiang, Sun, Bo‐Xun, Zhao, Zhi‐Wei, Chen, Xin, Xia, Wen‐Jin, Shen, Yuehai, Li, Ya‐Min
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 04.01.2022
Subjects
5-Chalcogenotriazoles
Alkynes
Cascade chemical reactions
Chalcogenides
Copper
Functional groups
Multicomponent reactions
Triazoles
β-Hydroxy chalcogenides
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Summary:A copper‐catalyzed four‐component cascade reaction for the preparation of triazoles bearing β‐hydroxy chalcogenides from terminal alkynes, azides, epoxides, and Se/K2S is reported. The present reaction proceeds under mild conditions, and exhibits a good functional group compatibility. A possible mechanism is proposed.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202100938