Nickel‐Catalyzed Selective Synthesis of α‐Alkylated Ketones via Dehydrogenative Cross‐Coupling of Primary and Secondary Alcohols
Herein, we describe an isolable, air‐stable, homogeneous, nickel catalyst that performs dehydrogenative cross‐coupling reaction between secondary and primary alcohols to result α‐alkylated ketone products selectively. The sequence of steps involve in this one‐pot reaction is dehydrogenation of both...
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Published in | Advanced synthesis & catalysis Vol. 364; no. 1; pp. 47 - 52 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Heidelberg
Wiley Subscription Services, Inc
04.01.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Herein, we describe an isolable, air‐stable, homogeneous, nickel catalyst that performs dehydrogenative cross‐coupling reaction between secondary and primary alcohols to result α‐alkylated ketone products selectively. The sequence of steps involve in this one‐pot reaction is dehydrogenation of both alcohols, condensation between the ketone and the aldehyde, and hydrogenation of the in situ‐generated α,β‐unsaturated ketone. Preliminary mechanistic investigation hints a radical mechanism following borrowing hydrogen reaction. |
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ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.202101077 |