Radical Cascade Reactions of β,γ‐Unsaturated Hydrazones/Oximes

Radical cascade cyclization of β,γ‐unsaturated hydrazones/oximes has recently emerged as an efficient and powerful protocol for the construction of diverse and valuable functionalized pyrazolines and isoxazolines. In this review, three catalytic ways of radical cascade cyclization of β,γ‐unsaturated...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 363; no. 20; pp. 4640 - 4666
Main Authors Si, Ya‐Feng, Lv, Qi‐Yan, Yu, Bing
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 19.10.2021
Subjects
Cascade chemical reactions
Functional groups
Hydrazones
isoxazolines
Organic chemistry
Oximes
pyrazolines
radical cascade cyclization
β,γ-unsaturated hydrazones/oximes
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Summary:Radical cascade cyclization of β,γ‐unsaturated hydrazones/oximes has recently emerged as an efficient and powerful protocol for the construction of diverse and valuable functionalized pyrazolines and isoxazolines. In this review, three catalytic ways of radical cascade cyclization of β,γ‐unsaturated hydrazones/oximes are summarized and classified; these are transition‐metal‐catalyzed systems, transition‐metal‐free systems, and photo‐/electrocatalytic systems, respectively. Through these methods, various functional groups are installed on the pyrazoline and isoxazoline skeletons to enrich the small organic molecule library.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202100807