Metal-Free Radical Annulation-Hydrofunctionalization of 1,6-Enynes for Stereoselective Synthesis of (E)-1-Indanones

• Published in: Asian journal of organic chemistry Vol. 9; no. 7; pp. 1040 - 1044
• Main Authors: Wu, Ya-Nan, Zhang, Tian-Shu, Hao, Wen-Juan, Tu, Shu-Jiang, Jiang, Bo
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.07.2020
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; 1,7-ENYNES; DESIGN; (E)-1-indanones; RECEPTOR ANTAGONISTS; hydrophosphinylation; radical annulation; FUNCTIONALIZATION; KETONES; BICYCLIZATION CASCADES; LIGANDS; metal-free transformations; INHIBITORS; OXIDES; hydrosulfonylation; CYCLIZATION

Two metal-free radical annulation-hydrofunctionalization cascades of 1,6-enynes have been established, enabling the complete stereoselectivity to access a wide range of functionalized (E)-1-indanones with moderate to good yields. The reaction pathways involve in situ-generated P- or S-centered radic...